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LSD Overdose

Signs and symptoms of LSD overdose include severe agitation, psychosis, and seizures.

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Lysergic acid diethylamide (LSD) is technically a toxin, so it is possible to consume enough to the point that bodily systems and organs can fail, leading to an overdose. However, it is very rare that an overdose on LSD occurs because it is usually taken in very small amounts. 

Can You Overdose on LSD?

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It is possible to overdose on LSD, though it is not particularly common in comparison with other drugs, such as opioids. 

An LSD overdose can be dangerous, and it is critical that you seek medical attention immediately if you or someone you know may be overdosing on the drug. An overdose can lead to severe and permanent psychological symptoms. 

How Much LSD Can Make You Overdose?

The exact amount of LSD that is needed in order to cause an overdose is not widely understood, as this amount varies greatly based on various factors. LSD is generally considered to be associated with a very low risk of a fatal overdose in comparison with other drugs like heroin. However, high doses can contribute to severely adverse psychological and physical symptoms. 

Recreational users of LSD often consume between 50 to 200 micrograms per session, with hallucinogenic effects being noticeable with this amount. An overdose becomes a possibility when the dose reaches approximately 1,000 micrograms or more.  

What Are the Signs & Symptoms of Overdosing on LSD?

The following are some of the most common signs and symptoms of an LSD overdose:

  • Hallucinations and delusions: LSD is a hallucinogenic, so an overdose on the drug may create hallucinations. 
  • Paranoia and/or elevated level of agitation: LSD can lead to changes in mood, such as agitation and paranoia. 
  • Psychosis: LSD can result in structural changes in the brain, causing psychosis and symptoms that can be experienced longitudinally. 
  • Seizures: Overdosing on LSD can lead to seizures and other neurological symptoms in rare cases. 
  • Increase in blood pressure and heart rate: A large dose of LSD can lead to an increase in heart rate and blood pressure. 

Risk Factors for LSD Overdose

The following factors may increase your risk of overdosing on LSD:

  • Interactions with other drugs: If you consume other drugs while also consuming LSD, you increase the risk of experiencing a severe interaction that can lead to an overdose. 
  • Dosage and strength of drug purity: A higher dosage or a higher level of purity will increase the risk of overdosing because there will be a higher concentration of the active ingredient in LSD in your bloodstream. 
  • Mental health factors: Individuals who experience certain mental health symptoms may face a higher risk of overdosing or experiencing a severe adverse reaction to overdose symptoms. Use of psychedelic drugs like LSD is linked to increased mental health issues
  • Individual factors. Several individual factors, such as your tolerance, medical history, and family history, can all impact your risk of overdosing and the ability to metabolize LSD once it has been consumed. 

What Happens When You Overdose on LSD? 

If you overdose on LSD, some of the following may occur:

  • Intensive delusions and hallucinations
  • Paranoia and mood changes
  • Psychosis 
  • Seizures
  • Changes in blood pressure

What Are the Long-Term Risks of Overdose?

Some of the long-term risks of an LSD overdose include the following:

  • Recurring flashbacks and hallucinations
  • Mental health issues and trauma
  • Psychotic symptoms
  • Increase in impulsivity and risk-taking behaviors

Though the risk of overdosing on LSD is relatively low, the symptoms can be serious. Seek medical attention as soon as possible if you experience any of those symptoms that have been listed above or if you see someone who is potentially experiencing an overdose. 

What to Do if Someone Is Overdosing on LSD

If you or someone you know is overdosing on LSD, call 911. If someone is unconscious, it may be necessary to clear their airway in order to prevent them from choking, particularly, if they are vomiting. 

For LSD overdose, medical professionals will generally administer supportive care, keeping the patient calm and protected in a soothing environment. IV fluids may be administered as needed, and certain medications may be prescribed to address specific symptoms.

Overdosing on LSD is a sign of a substance abuse problem. With professional help, you can stop using LSD and eliminate your future overdose risk.

Updated March 21, 2024
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