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How Long Does LSD Stay in Your System?

On average, LSD can be detected on a urine drug test for one to five days following use. While you may feel the effects of LSD for about 12 hours, it remains in the body for much longer than that.

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The specific length of time that LSD remains in your system depends on a wide range of factors, including dosage, your own level of metabolism, and the duration of time you have taken the drug. Additionally, LSD remains in different parts of your body for different lengths of time, such as within the hair, blood, and urine. 

Quick Facts About LSD Half-Life

Half-life refers to the length of time that it takes for the concentration of a particular substance that has been consumed and entered the bloodstream to be reduced by 50 percent. The half-life of LSD is generally about three to five hours for most people. This means that after a duration of approximately three to five hours, half of the LSD that one has consumed has been metabolized and cleared from the body. 

The following clearance times exist for the average adult person who has consumed LSD for various parts of the body:

  • Blood: LSD can be detected in the blood for 6 to 12 hours following consumption of the drug. 
  • Hair: After consuming LSD, the drug can be detected for up to 90 days in human hair. 
  • Urine: LSD can be detected in the urine for at least one to three days, but it can potentially be detected for up to five days in some people. 

The length of time that LSD remains in one’s system depends on many factors, such as the length of time you have been using and how much you have taken. Age, weight, height, and any health conditions can also influence how long it remains in the body. 

For the average adult, the effects of LSD can be felt within 30 minutes to one hour and can last for up to 12 hours or even longer.

How Is LSD Metabolized? 

LSD is a powerful hallucinogenic drug that can significantly alter perception. Individual metabolism is an important factor in determining how long LSD remains in the body. 

LSD is predominantly metabolized in the liver. When LSD is metabolized, various metabolites are produced, including 2-oxo-3-hydroxy-LSD (O-H-LSD), and these metabolites are what are detected in the aforementioned tests. 

The metabolic process involved in the elimination of LSD involves cytochrome P450 enzymes, which are integral in the metabolism of toxins like drugs. The primary metabolic pathways involved in LSD removal include the following:

  • N-demethylation: This consists of the removal of the methyl group from the LSD molecule, leading to the production of compounds like nor-LSD. 
  • Hydrolysis: This involves the metabolism of the chemical bond within the LSD molecule via water, leading to the production of diethylamide and lysergic acid. 
  • Glucuronidation: This process consists of the addition of a molecule of glucuronic acid to LSD and its metabolites, helping in their removal via urine. 

After LSD is metabolized, it is eliminated from the body primarily through the kidneys via urine. 

Factors That Affect LSD´s Duration in Your Body

There are several factors that can influence the length of time that LSD remains in the body. Some of the main factors include the following:

  • Dose: The amount of LSD that you have taken will significantly influence how long it remains in your system, as higher doses require more time to metabolize. 
  • Personal level of metabolism. A higher level of metabolism will assist in the removal of LSD, while a slow metabolism will ensure that a longer amount of time is needed. 
  • Body composition: In general, a larger body composition (either being taller or heavier) will take a longer amount of time to metabolize LSD. 
  • Age: Being older will most likely indicate that LSD will remain in your body longer than it will for younger individuals. 
  • Organ function: The functioning of your kidneys and liver will significantly influence your metabolism and ability to process toxins like LSD. 
  • Consumption of other substances. If you have taken other substances along with LSD, it will take more time to fully eliminate them all from your system. 

Breaking Down LSD in Your Body

The half-life of LSD is about three to five hours. The following chart reflects the timelines by which LSD will be detectable on certain types of drug tests:

Type of Drug TestTimeline
Blood6–12 hours
Urine1–3 days
HairUp to 90 days
Saliva1–2 days

It is important to note that these time frames vary by individual. There is no way to “beat” a drug test. If you need to take one, the best way to pass it is to avoid drug use altogether.

Signs of LSD Abuse

Drug abuse refers to the use of a drug in any way other than as medically prescribed, so any form of LSD use would be considered abuse in most contexts. There are some places where laws related to LSD use have become more relaxed. There is also some evidence to show that LSD, in controlled doses, can be effective for addressing some mental health issues. If you are using LSD recreationally, it is considered abuse. 

Some of the most notable signs of LSD abuse include the following:

If you regularly abuse LSD and are unable to stop this use, it’s a sign that addiction has formed.

  • Hallucinations
  • Altered perception
  • Mood alterations
  • Changes in thought processes and patterns
  • Dilated pupils
  • Increase in body temperature
  • Elevated blood pressure
  • Elevated heart rate
  • Reduction in appetite
  • Nausea 
  • Vomiting
  • Insomnia
  • Impulsive behavior
  • Social withdrawal
  • Preoccupation with locating LSD and/or the discussion of psychedelic experiences

If you regularly abuse LSD and are unable to stop this use, it’s a sign that addiction has formed.

Updated June 8, 2023
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